SWATH® Acquisition Enables the Ultra-Fast and Accurate Determination of Novel Synthetic Opioids

Cabrices OG, Krotulski AJ, Fiorentin TR, Logan BK, Taylor AM

Sciex

Novel synthetic opioids continue to cause widespread intoxications resulting in fatalities worldwide. As these compounds continue to surge within society, their timely and accurate detection is crucial to forensic investigators. Analysis of seized powders is highly contingent on specific and sensitive screening applications.

The combination of LC separations with SWATH® Acquisition, on a TripleTOF® or X500R system, gives forensic investigators a higher level of confidence in modern, synthetic opioid characterization by reliably obtaining comprehensive MS/MS spectral fragment information on every detectable component in the sample. Furthermore, it permits high throughput sample analysis, which can help reduce case backlog.

In this technical note, the use of SWATH® Acquisition for the ultra-fast and accurate identification of novel synthetic opioids present in different seized drug samples was evaluated, and compared to typical GC/MS analysis.

Full Article
This email address is being protected from spambots. You need JavaScript enabled to view it.