Detection of xylazine in whole blood samples using high resolution mass spectrometry

Reyes AG, Krotulski AJ, Oetjen K, Chay L

SCIEX Tech Note


Abstract

This technical note describes a non-target acquisition method for the simultaneous screening and quantitation of the emerging drug xylazine in authentic human whole blood sample. Using the SCIEX X500R system, the MS/MS spectra were searched against a user-generated library database for compound confirmation. This screening method revealed detectable levels of xylazine in 4 of 7 authentic whole blood samples suspected to contain fentanyl and/or other opioids (Figure 1). The screening method also revealed the presence of additional drugs in the blood samples.

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