Quetiapine: A Toxic Adulterant Found in Illicit Drugs

Quetiapine is an atypical antipsychotic agent that is FDA approved for the treatment of schizophrenia, acute manic episodes, and major depressive disorder. The drug also has several off-label indications, such as generalized anxiety disorder, insomnia, and chronic PTSD. Daily doses in adults usually range from 150 to 800 mg, but higher doses are utilized with QT interval monitoring. Somnolence, dizziness, and orthostatic hypotension are common adverse effects. QTc interval prolongation is associated with torsade de pointes, a potentially lethal dysrhythmia.
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