N-Pyrrolidino Isotonitazene
The following information was compiled in December 2024 and is subject to change as new research is conducted and as new information becomes available:
Description: N-Pyrrolidino isotonitazene is a novel synthetic opioid bearing structural resemblance to isotonitazene, N-pyrrolidino protonitazene, N-pyrrolidino etonitazene, and other nitazene (2-benzylbenzimidazole) analogues. N-Pyrrolidino isotonitazene is a positional isomer of N-pyrrolidino protonitazene. N-Pyrrolidino isotonitazene was first identified in September 2024 by CanTEST and subsequently in October 2024 by drug checking services in Australia.1,2 N-Pyrrolidino isotonitazene was identified in October 2024 by our laboratory and confirmed using standard reference material.
Sample Source: Montgomery County Coroner’s Office (Dayton, OH)
Sample Appearance: Blood specimen
Pharmacology: In vitro data available show that N-pyrrolidino isotonitazene is a potent mu-opioid receptor agonist (EC50: 0.288 nM, Emax: 216% to hydromorphone).3
Toxicology: N-Pyrrolidino isotonitazene has been identified in one toxicology case to date at the CFSRE.
Drug Materials: N-Pyrrolidino isotonitazene has not yet been detected in drug materials at the CFSRE.
Demographics / Geographics: N-Pyrrolidino isotonitazene was identified in one blood specimen from Ohio and was found alongside the designer benzodiazepine etizolam.
Legal Status: N-Pyrrolidino isotonitazene is not currently a scheduled drug in the United States.
- Class:
- Opioid
- Appearance:
- Blood
- Formula:
- C23H28N4O3
- MW:
- 408.5
- [M+]:
- 408
- [M+H]+:
- 409.2234
- IUPAC:
- 2-[(4-isopropoxyphenyl)methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)benzimidazole
- Report Date:
- December 20, 2024