N-Pyrrolidino Isotonitazene

The following information was compiled in December 2024 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Pyrrolidino isotonitazene is a novel synthetic opioid bearing structural resemblance to isotonitazene, N-pyrrolidino protonitazene, N-pyrrolidino etonitazene, and other nitazene (2-benzylbenzimidazole) analogues. N-Pyrrolidino isotonitazene is a positional isomer of N-pyrrolidino protonitazene. N-Pyrrolidino isotonitazene was first identified in September 2024 by CanTEST and subsequently in October 2024 by drug checking services in Australia.1,2 N-Pyrrolidino isotonitazene was identified in October 2024 by our laboratory and confirmed using standard reference material.

Sample Source: Montgomery County Coroner’s Office (Dayton, OH)

Sample Appearance: Blood specimen

Pharmacology: In vitro data available show that N-pyrrolidino isotonitazene is a potent mu-opioid receptor agonist (EC50: 0.288 nM, Emax: 216% to hydromorphone).3

Toxicology: N-Pyrrolidino isotonitazene has been identified in one toxicology case to date at the CFSRE.

Drug Materials: N-Pyrrolidino isotonitazene has not yet been detected in drug materials at the CFSRE.

Demographics / Geographics: N-Pyrrolidino isotonitazene was identified in one blood specimen from Ohio and was found alongside the designer benzodiazepine etizolam.

Legal Status: N-Pyrrolidino isotonitazene is not currently a scheduled drug in the United States.



Class:
Opioid
Appearance:
Blood
Formula:
C23H28N4O3
MW:
408.5
[M+]:
408
[M+H]+:
409.2234
IUPAC:
2-[(4-isopropoxyphenyl)methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)benzimidazole
Report Date:
December 20, 2024
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