N-Propionitrile Chlorphine

The following information was compiled in December 2024 and is subject to change as new research is conducted and as new information becomes available:

Description: N-Propionitrile chlorphine is a novel synthetic opioid bearing structural similarity to other benzimidazolones (e.g., brorphine, chlorphine, florphine). N-Propionitrile chlorphine was first identified by our laboratory in August 2024 and confirmed in September 2024 via standard reference material.

Sample Source: Tapestry  in Collaboration with StreetCheck

Sample Appearance: White material

Pharmacology: There is no pharmacological data currently available for N-propionitrile chlorphine; however, based on in vitro pharmacological evaluation of chlorphine, it is assumed that N-propionitrile chlorphine would retain mu-opioid receptor agonist activity.¹

Toxicology: N-Propionitrile chlorphine has identified in one toxicology case to date at the CFSRE.

Drug Materials: N-Propionitrile chlorphine has been detected in one drug material to date at the CFSRE.

Demographics / Geographics: The drug material positive for N-propionitrile chlorphine originated from Connecticut and was identified alongside its benzimidazolone counterpart chlorphine. The toxicology case positive for N-propionitrile chlorphine originated from New York and was identified alongside the designer benzodiazepine phenazolam.

Legal Status: N-Propionitrile chlorphine is not currently a scheduled drug in the United States.

Class:

Opioid

Appearance:

White material

Formula:

C23H25ClN4O

MW:

408.9

[M+]:

408

[M+H]+:

409.1790

IUPAC:

3-[3-[1-[1-(4-chlorophenyl)ethyl]-4-piperidyl]-2-oxo-benzimidazol-1-yl]propanenitrile

Report Date:

December 17, 2024